Estalis
Estalis is a hormone replacement therapy (HRT) patch for women after menopause, helping with symptoms like hot flashes and preventing bone thinning.
Form
depotlaastari
Strength
50 / 250 mikrog / 24 tuntia
Active Ingredient
Estradiol hemihydrate
Manufacturer
Sandoz A/S
How to Use
Dosage
Apply one Estalis patch to your skin, changing it twice a week.
Method
Apply the patch to your lower stomach, below the waist. Do not apply it to your breasts or waistline. Press it firmly with your palm for at least 10 seconds, especially around the edges.
Important
Only wear one patch at a time. Do not apply a second patch if you forget to change one.
Possible Side Effects
COMMON
- •Headache
- •Skin reactions at the patch application site (e.g., irritation, burning, rash, dryness, bleeding, bruising, inflammation, swelling, skin discoloration, hives, or blisters)
- •Breast pain or tenderness
- •Menstrual pain
- •Menstrual cycle disturbances
- •Dizziness
- •Nervousness
- •Insomnia (difficulty sleeping)
- •Mood changes
- •Depression
- •Nausea (feeling sick)
- •Abdominal bloating
- •Indigestion
- •Diarrhea
- •Abdominal pain
- •Acne
- •Rash
- •Itching
- •Dry skin
- •Back pain
- •Pain in legs and arms
- •General aches
- •Weakness
- •Weight changes
- •Swelling in the arms or legs
- •Breast enlargement
- •Abnormally heavy menstrual bleeding
- •Vaginal discharge
- •Irregular vaginal bleeding or spotting
- •Uterine contractions
- •Vaginal inflammation
- •Growth of the uterine lining
RARE
- •Migraine
- •Vertigo (spinning sensation)
- •Vomiting
- •Skin discoloration
- •Increased blood pressure
- •Varicose veins
- •Breast cancer
- •Elevated liver enzyme levels
- •Muscle weakness
- •Blood clot
- •Allergic reactions (e.g., rash, itching, difficulty breathing)
- •Changes in sexual desire
- •Tingling or prickling sensations
- •Gallstones
- •Gallbladder disorders
- •Cysts near the fallopian tubes
- •Uterine fibroids
- •Cervical polyps
- •Yellowing of skin/eyes due to bile flow problems (cholestatic jaundice)
- •Hair loss
- •Allergic skin inflammation
- •Severe allergic reactions (e.g., difficulty breathing; swelling of the face, tongue, throat, or skin; dizziness; hives)
- •Gallbladder disease
- •Various skin conditions (e.g., discolored skin patches, especially on face and neck ("pregnancy spots"), painful red lumps on skin, ring-shaped red or sore rashes)
- •Impaired memory and thinking (possible dementia)
- •Dry eyes
- •Difficulty with contact lenses
Important Warnings
- Do not use if you have or have had breast cancer, or if breast cancer is suspected.
- Do not use if you have or are suspected of having an estrogen-dependent cancer, such as uterine cancer.
- Do not use if you have unexplained vaginal bleeding.
- Do not use if you have a significantly thickened uterine lining that has not been treated.
- Do not use if you have or have had a blood clot in a vein (e.g., in your leg or lungs).
Show 13 more warnings
- Do not use if you have a blood clotting disorder.
- Do not use if you have or have recently had a disease caused by arterial blood clots, such as a heart attack, stroke, or angina (chest pain).
- Do not use if you have liver disease and your liver function tests are not yet normal.
- Do not use if you have a rare inherited blood disorder called porphyria.
- Do not use if you are allergic to estradiol, norethisterone, or any other ingredients in Estalis.
- Stop using Estalis and contact your doctor immediately if any of the above conditions appear for the first time or get worse.
- Stop using Estalis and contact your doctor immediately if your skin or the whites of your eyes turn yellow (jaundice), as this may indicate liver problems.
- Stop using Estalis and contact your doctor immediately if you experience swelling of the face, tongue, or throat, difficulty swallowing, or hives with breathing difficulties, as these may be signs of a serious allergic reaction.
- Stop using Estalis and contact your doctor immediately if your blood pressure increases significantly (symptoms may include headache, tiredness, dizziness).
- Stop using Estalis and contact your doctor immediately if you get migraine-like headaches for the first time.
- Stop using Estalis and contact your doctor immediately if you become pregnant.
- Stop using Estalis and contact your doctor immediately if you notice signs of a blood clot, such as painful swelling and redness in a leg, sudden chest pain, or difficulty breathing.
- Check your breasts regularly. See a doctor if you notice any changes, such as dimpling of the skin, changes to your nipple, or any lumps you can see or feel.
Use in Elderly Patients
Category D
Systemic use: Avoid use in older adults. In systemic use, consider potential adverse effects, such as risk of cardiovascular diseases and venous thromboembolism. Consider potential interactions. (updated 21.10.2024)